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Article

Central nervous system relapse after allogeneic HCT in FLT3-mutated AML.

Annals of hematology - 1 Dec 2024

Kouidri Khouloud, Acker Fabian, Toenges Rosa, Pfaff Saskia, Lindner Sarah, Riemann Julia, Werth Marek, Ajib Salem, Lang Fabian, Steffen Björn, Oellerich Thomas, Serve Hubert, Cremer Anjali, Bug Gesine

Abstract excerpt

Central nervous system (CNS) relapse in acute myeloid leukemia (AML) is rare, but prognostically extremely unfavorable and associated with very high mortality rates. Aim of our single-center study was to define risk factors for CNS relapse in patients with FLT3-mutated AML after allogeneic hematopoietic cell transplantation (HCT) and to determine the impact of pre-emptive or salvage therapy with FLT3-inhibitors...

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Identifiers

PMID: 39589497
DOI: 10.1007/s00277-024-06106-y
PMCID: PMC11695448

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