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Article

Metabolic stress in space: ROS-induced mutations in mice hint at a new path to cancer.

Redox biology - 1 Dec 2024

Stolc Viktor, Karhanek Miloslav, Freund Friedemann, Griko Yuri, Loftus David J, Ohayon Maurice M

Abstract excerpt

Long-duration spaceflight beyond Earth's magnetosphere poses serious health risks, including muscle atrophy, bone loss, liver and kidney damage, and the Spaceflight-Associated Neuro-ocular Syndrome (SANS). RNA-seq of mice aboard the International Space Station (ISS) for 37 days revealed extraordinary hypermutation in tissue-specific genes, with guanine base conversion predominating, potentially contributing to...

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Identifiers

PMID: 39586121
DOI: 10.1016/j.redox.2024.103398
PMCID: PMC11625351

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