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Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion– and γ-ray–induced tumors

15 Apr 2020

Abstract excerpt

Cancer risk from galactic cosmic radiation exposure is considered a potential "showstopper" for a manned mission to Mars. Calculating the actual risks confronted by spaceflight crews is complicated by our limited understanding of the carcinogenic effects of high-charge, high-energy (HZE) ions, a radiation type for which no human exposure data exist. Using a mouse model of genetic diversity, we find that the...

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PMID: 32494593
DOI: 10.1126/sciadv.aax5940

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