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Identification of compounds from natural Peruvian sources as potential inhibitors of SARS-CoV-2 Mpro mutations by virtual screening and computational simulations.

F1000Research - 1 Jan 2024

Barazorda-Ccahuana Haruna Luz, Cárcamo Rodriguez Eymi Gladys, Centeno-Lopez Angela Emperatriz, Paco-Chipana Margot, Goyzueta-Mamani Luis Daniel, Chavez-Fumagalli Miguel Angel

Abstract excerpt

Background: Although the COVID-19 pandemic has diminished in intensity, the virus continues to circulate globally. The SARS-CoV-2 main protease (Mpro) is a key enzyme in the life cycle of the virus, making it important for the development of treatments against future variants of the virus. In this work, Peruvian natural compounds were evaluated against different mutations of the SARS-CoV-2 Mpro. Methods: In...

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Identifiers

PMID: 39583212
DOI: 10.12688/f1000research.143633.3
PMCID: PMC11585855

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