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Article

Homologous recombination deficiency in pancreatic neuroendocrine tumors.

Future oncology (London, England) - 1 Dec 2024

Bardasi Camilla, Tenedini Elena, Bonamici Lia, Benatti Stefania, Bonetti Luca Reggiani, Luppi Gabriele, Cortesi Laura, Tagliafico Enrico, Dominici Massimo, Gelsomino Fabio

Abstract excerpt

Aim: Pancreatic Neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms whose tumor biology is still little known. Thanks to next-generation sequencing, pathogenic mutations in base-excision-repair MUTYH gene and homologous recombination genes CHEK2 and BRCA2 seem to have a role in the development of pNETs.Research design & methods: We assumed that Homologous Recombination Deficiency (HRD) could be a...

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Identifiers

PMID: 39582314
DOI: 10.1080/14796694.2024.2421160
PMCID: PMC11633435

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