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Article

Genetic Determinants of Left Atrial Function Are Associated With Stroke.

Journal of the American Heart Association - 3 Dec 2024

Vad Oliver B, Paludan-Müller Christian, Diederichsen Søren Z, McKaige Emily A, Monfort Laia M, Lundegaard Pia R, Bertelsen Litten, Andreasen Laura, Svendsen Jesper H, Olesen Morten S

Abstract excerpt

BACKGROUND: While atrial fibrillation (AF) is a key risk factor for stroke, recent studies have suggested that atrial cardiomyopathy may also increase stroke risk in the absence of AF. This study aimed to evaluate genetic determinants for left atrial (LA) function and volumes and risk of stroke. METHODS AND RESULTS: Polygenic scores (PGSs) for LA measures were constructed and used in 380 017 individuals in the UK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39575717
DOI: 10.1161/JAHA.124.037490
PMCID: PMC11681563

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