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Improving stool sample processing and pyrosequencing for quantifying benzimidazole resistance alleles in Trichuris trichiura and Necator americanus pooled eggs.

Parasites & vectors - 25 Sept 2021

Gandasegui Javier, Grau-Pujol Berta, Cambra-Pelleja María, Escola Valdemiro, Demontis Maria Antonietta, Cossa Anelsio, Jamine José Carlos, Balaña-Fouce Rafael, van Lieshout Lisette, Muñoz José, Martínez-Valladares María

Abstract excerpt

BACKGROUND: There is an urgent need for an extensive evaluation of benzimidazole efficacy in humans. In veterinary science, benzimidazole resistance has been mainly associated with three single-nucleotide polymorphisms (SNPs) in the isotype-1 β-tubulin gene. In this study, we optimized the stool sample processing methodology and resistance allele frequency assessment in Trichuris trichiura and Necator americanus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34563247
DOI: 10.1186/s13071-021-04941-w
PMCID: PMC8466976

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