Article
Genetics and pathophysiology of diffuse idiopathic skeletal hyperostosis.
Frontiers in endocrinology - 1 Jan 2026
Ji Wenhao, Yang Wanlei, Su Shikang, Sun Simin, Cai Huanhao, Wang Kangnan, Pan Bin, Qian Yu
Abstract excerpt
Diffuse Idiopathic Skeletal Hyperostosis (DISH) is a systemic condition primarily characterized by flowing ossification along the anterolateral aspects of the spine, often leading to back pain, dysphagia, and an increased risk of spinal fractures. Despite its significant clinical burden and high prevalence among the elderly, DISH remains underdiagnosed and poorly understood, with no disease-modifying therapies...
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