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Article

Maternal exercise represses FGF21 via SIRT1 to improve the phenotypic transformation of vascular smooth muscle in hypertensive offspring.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jan 2025

Shan Meiling, Qiu Fang, Li Peng, Zhang Yanyan, Shi Lijun

Abstract excerpt

Maternal exercise during pregnancy is widely recognized as an effective means of promoting cardiovascular health in offspring. Few studies have explored how maternal exercise impacts vascular function and phenotypic switching in hypertensive offspring, despite the known involvement of vascular structural and functional remodeling in hypertension pathogenesis. Research indicates a significant relationship between...

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Source

Identifiers

PMID: 39543417
DOI: 10.1038/s41440-024-01991-2

Genes

FGF21
SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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