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Dengue virus genomic surveillance in the applying Wolbachia to eliminate dengue trial reveals genotypic efficacy and disruption of focal transmission.

Scientific reports - 14 Nov 2024

Edenborough Kathryn, Supriyati Endah, Dufault Suzanne, Arguni Eggi, Indriani Citra, Denton Jai, Sasmono R Tedjo, Ahmad Riris Andono, Anders Katherine L, Simmons Cameron P

Abstract excerpt

Release of Aedes aegypti mosquitoes infected with Wolbachia pipientis (wMel strain) is a biocontrol approach against Ae. aegypti-transmitted arboviruses. The Applying Wolbachia to Eliminate Dengue (AWED) cluster-randomised trial was conducted in Yogyakarta, Indonesia in 2018-2020 and provided pivotal evidence for the efficacy of wMel-Ae. aegypti mosquito population replacement in significantly reducing the...

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Identifiers

PMID: 39543157
DOI: 10.1038/s41598-024-78008-y
PMCID: PMC11564853

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