Article
Assessing Wolbachia-mediated sterility for dengue control: emulation of a cluster-randomized target trial in Singapore
6 Aug 2024
Abstract excerpt
BACKGROUND: Matings between male Aedes aegypti mosquitoes infected with wAlbB strain of Wolbachia and wildtype females yield non-viable eggs. We evaluated the efficacy of releasing wAlbB-infected Ae. aegypti male mosquitoes to suppress dengue. METHODS: We specified the protocol of a two-arm cluster-randomized test-negative controlled trial (cRCT) and emulated it using a nationally representative...
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