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Genetic associations of miRNA variants (miR-10a, miR-30c, miR-181a, miR-499b) with primary ovarian insufficiency in Korean women.

Maturitas - 1 Jan 2025

An Hui Jeong, Cho Sung Hwan, Ryu Chang Soo, Ko Eun Ju, Park Hyeon Woo, Kim Young Ran, Ahn Eun Hee, Shin Ji Eun, Joo Seong-Soo, Kim Ji Hyang, Kim Nam Keun

Abstract excerpt

OBJECTIVES: MicroRNAs (miRNAs) are pivotal in post-transcriptionally modulating gene expression in both animals and plants. This study investigates the relationship between microRNA polymorphisms and the occurrence of primary ovarian insufficiency in Korean women. Our hypothesis posits that polymorphisms in microRNAs-specifically miR-10aA > T, miR-30cA > G, miR-181aT > C, and miR-499bA > G-may be linked to...

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PMID: 39536656
DOI: 10.1016/j.maturitas.2024.108153

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