[Epigenetic mechanisms of the interrelations of osteoarthritis with aging.]

Abstract excerpt

A hypothesis is presented according to which the activation of retroelements during aging, causing immune reactions in the human body, is a trigger for the development of osteoarthritis. Predisposition factors for this are polymorphisms associated with osteoarthritis, located in intronic and intergenic regions where transposable elements are localized. In inflamed joints, changes in the expression of many genes...

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