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Article

Cytologic and Molecular Assessment of Isthmus Thyroid Nodules and Carcinomas.

Thyroid : official journal of the American Thyroid Association - 1 Mar 2025

Jasim Sina, Golding Allan, Bimston David, Alshalalfa Mohammed, Chen Yang, Jiang Ruochen, Hao Yangyang, Huang Jing, Klopper Joshua P, Kloos Richard T, Brown Taylor C

Abstract excerpt

Background: Isthmic thyroid nodules are more likely to be malignant and isthmic differentiated thyroid cancer demonstrates less favorable behavior compared with lobar locations. The goal of this study was to assess molecular differences of thyroid nodules and carcinomas from the isthmus relative to the lobes. Methods: The Afirma thyroid nodule database (n = 177,227) was assessed for cytologic and molecular...

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Identifiers

PMID: 39527399
DOI: 10.1089/thy.2024.0254

Genes

BRAF
ALK
NRAS
PAX8
RET
SPOP

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