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Assessment of Single-Cycle M-Protein Mutated Vesicular Stomatitis Virus as a Safe and Immunogenic Mucosal Vaccine Platform for SARS-CoV-2 Immunogen Delivery.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Dec 2024

Zhang En, Ke Yong, Ran Weihong, Zhang Yu, Li Ruihang, Fang Xinkui, Wang Lei, Zhang Baohong, Sun Tao

Abstract excerpt

The goal of the next-generation COVID-19 vaccine is to provide rapid respiratory tract protection with a single dose. Circulating antibodies do not protect the olfactory mucosa from viral infection, necessitating localized mucosal immunization. Live attenuated vesicular stomatitis virus (VSVMT)-based COVID-19 vaccines effectively stimulate mucosal immunity in animals, though safety concerns remain, particularly...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39526809
DOI: 10.1002/advs.202404197
PMCID: PMC11653642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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