Article
Genome-Wide Transcription and Functional Analyses Reveal Heterogeneous Molecular Mechanisms Driving Pyrethroids Resistance in the Major Malaria Vector Anopheles funestus Across Africa.
G3 (Bethesda, Md.) - 7 Jun 2017
Riveron Jacob M, Ibrahim Sulaiman S, Mulamba Charles, Djouaka Rousseau, Irving Helen, Wondji Murielle J, Ishak Intan H, Wondji Charles S
Abstract excerpt
Pyrethroid resistance in malaria vector, An. funestus is increasingly reported across Africa, threatening the sustainability of pyrethroid-based control interventions, including long lasting insecticidal nets (LLINs). Managing this problem requires understanding of the molecular basis of the resistance from different regions of the continent, to establish whether it is being driven by a single or independent...
Topics
- Africa
- Alleles
- Animals
- Anopheles
- Computational Biology
- Cytochrome P-450 Enzyme System
- Gene Expression Profiling
- Gene Ontology
- Genetic Heterogeneity
- Genetic Variation