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Article

Associations between methylenetetrahydrofolate reductase polymorphisms and hepatocellular carcinoma risk: An update meta-analysis and trial sequential analysis.

Medicine - 15 Oct 2021

Wang Binfeng, Ma Miaomiao, Guo Xiaojun, Yan Yan, Li Lang

Abstract excerpt

AIM: To evaluate the associations between the methylenetetrahydrofolate reductase (MTHFR) single-nucleotide polymorphisms (SNPs) and hepatocellular carcinoma (HCC) with meta-analysis and trial sequential analysis. METHODS: PubMed, Embase, the Google Scholar, Wan fang database, VIP database, and China National Knowledge Infrastructure were extensively searched before April 2021. Odds ratios (ORs) and 95%...

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Identifiers

PMID: 34731145
DOI: 10.1097/MD.0000000000027527
PMCID: PMC8519208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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