Article
High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene.
Nature communications - 6 Nov 2024
Rahimov Fedik, Nieminen Pekka, Kumari Priyanka, Juuri Emma, Nikopensius Tiit, Paraiso Kitt, German Jakob, Karvanen Antti, Kals Mart, Elnahas Abdelrahman G, Karjalainen Juha, Kurki Mitja, Palotie Aarno, Heliövaara Arja, Esko Tõnu, Jukarainen Sakari, Palta Priit, Ganna Andrea, Patni Anjali P, Mar Daniel, Bomsztyk Karol, Mathieu Julie, Ruohola-Baker Hannele, Visel Axel, Fakhouri Walid D, Schutte Brian C, Cornell Robert A, Rice David P
Abstract excerpt
In Finland, the frequency of isolated cleft palate (CP) is higher than that of isolated cleft lip with or without cleft palate (CL/P). This trend contrasts to that in other European countries but its genetic underpinnings are unknown. We conducted a genome-wide association study in the Finnish population and identified rs570516915, a single nucleotide polymorphism highly enriched in Finns, as strongly associated...
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