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Article

Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations.

Reproductive toxicology (Elmsford, N.Y.) - 1 Dec 2012

Manikkam Mohan, Tracey Rebecca, Guerrero-Bosagna Carlos, Skinner Michael K

Abstract excerpt

Environmental compounds are known to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a "pesticide mixture" (pesticide permethrin and insect repellent N,N-diethyl-meta-toluamide, DEET) promotes epigenetic transgenerational inheritance of disease and associated DNA methylation epimutations in sperm. Gestating F0 generation female rats were exposed during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22975477
DOI: 10.1016/j.reprotox.2012.08.010
PMCID: PMC3513590

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