Article
Genetic linkage disequilibrium of deleterious mutations in threatened mammals.
EMBO reports - 1 Dec 2024
Hu Chunyan, Liu Gaoming, Zhang Zhan, Pan Qi, Zhang Xiaoxiao, Liu Weiqiang, Li Zihao, Li Meng, Zhu Pingfen, Ji Ting, Garber Paul A, Zhou Xuming
Abstract excerpt
The impact of negative selection against deleterious mutations in endangered species remains underexplored. Recent studies have measured mutation load by comparing the accumulation of deleterious mutations, however, this method is most effective when comparing within and between populations of phylogenetically closely related species. Here, we introduced new statistics, LDcor, and its standardized form nLDcor,...
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