Article
Single cell analysis of Idh mutant growth plates identifies cell populations responsible for longitudinal bone growth and enchondroma formation.
Scientific reports - 31 Oct 2024
Puviindran Vijitha, Shimada Eijiro, Huang Zeyu, Ma Xinyi, Ban Ga I, Xiang Yu, Zhang Hongyuan, Ou Jianhong, Wei Xiaolin, Nakagawa Makoto, Martin John, Diao Yarui, Alman Benjamin A
Abstract excerpt
Enchondromas are a common tumor in bone that can occur as multiple lesions in enchondromatosis, which is associated with deformity of the affected bone. These lesions harbor somatic mutations in IDH and driving expression of a mutant Idh1 in Col2 expressing cells in mice causes an enchondromatosis phenotype. Here we compared growth plates from E18.5 mice expressing a mutant Idh1 with control littermates using...
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