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Article

PTPN2 dephosphorylates STAT3 to ameliorate anesthesia-induced cognitive decline in aged rats by altering the microglial phenotype and inhibiting inflammation.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jan 2025

Zhao Xiaochun, Wang Xueting, Xu Ziyang, Chang Xiaohan, Tian Yue

Abstract excerpt

Perioperative neurocognitive disorders (PNDs) are common neurological complications after anesthesia in the elderly. Protein tyrosine phosphatase non-receptor type 2 (PTPN2) regulates signal transducer and activator of transcription protein 3 (STAT3) signaling to control inflammation in certain organs, but its role in PNDs remains unknown. Herein, we constructed a PND model in 18-month-old rats by treating them...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39481492
DOI: 10.1016/j.bbadis.2024.167545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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