Cascade testing effectively identifies undiagnosed sickle cell disease in The Gambia: a quality improvement project.

Abstract excerpt

OBJECTIVE: Sickle cell disease (SCD) has a high mortality during childhood in many low and middle-income countries (LMICs). Early diagnosis improves outcomes but newborn screening is not well established in LMICs. Cascade testing may be feasible and effective in identifying undiagnosed SCD and carriers of haemoglobin (Hb) S. DESIGN: Quality improvement project using existing clinic and laboratory resources....

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