Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sphingosine Kinase 2 Controls the Aggressive Phenotype of Oral Squamous Cell Carcinoma by Regulating miR-205 and miR-296 through p53.

The American journal of pathology - 1 Feb 2025

Milan Thaís Moré, Silva Gabriel, Sousa Lucas Oliveira, Leopoldino Andréia Machado

Abstract excerpt

Alterations in miRNAs, p53, and sphingolipid metabolism are associated with head and neck squamous cell carcinoma (HNSCC). However, the role of sphingosine kinase (SK)-2, an enzyme crucial for sphingolipid metabolism, is poorly understood in HNSCC. The aim of this study was to investigate how SK2 and p53 interact to regulate miRNAs miR-205 and miR-296. Analysis of small-RNA sequencing data from nontumor oral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to MicroRNAs

Share to Mouth Neoplasms

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 39476954
DOI: 10.1016/j.ajpath.2024.09.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sphingosine Kinase 2 Controls the Aggressive Phenotype of Oral Squamous Cell Carcinoma by Regulating miR-205 and miR-296 through p53.PMID 39476954Read ↗

Profile of sphingolipid-related genes and its association with prognosis highlights sphingolipid metabolism in oral cancerSemantic proximity Read ↗

RNA-sequencing manifests the intrinsic role of MAPKAPK2 in facilitating molecular crosstalk during HNSCC pathogenesisSemantic proximity Read ↗

PKM2 Modulation in Head and Neck Squamous Cell Carcinoma.Semantic proximity Read ↗

Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): Attenuation of C18-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasisSemantic proximity Read ↗

Correlation of Skp2 overexpression to prognosis of patients with nasopharyngeal carcinoma from South ChinaSemantic proximity Read ↗

miR-205 promotes proliferation and invasion of laryngeal squamous cell carcinoma by suppressing CDK2AP1 expressionSemantic proximity Read ↗

Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.Semantic proximity Read ↗

MicroRNA 617 Targeting SERPINE1 Inhibited the Progression of Oral Squamous Cell CarcinomaSemantic proximity Read ↗

The Prognostic Role of miR-195 in Head and Neck Squamous Cell Carcinoma: Systematic Review with Meta-Analysis and Trial Sequential AnalysisSemantic proximity Read ↗

Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinomaSemantic proximity Read ↗

p62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-kinase pathway inhibitors.Semantic proximity Read ↗

Acid Ceramidase: A Novel Therapeutic Target in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.