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Rapid and supersensitive allele detection of Plasmodium falciparum chloroquine resistance via a Pyrococcus furiosus argonaute-triggered dual-signal biosensing platform.

Parasites & vectors - 24 Nov 2024

Chen Liying, Chen Wencheng, Wei Huagui, Lin Wenai, Zhang Cheng, Hu Hongfei, Wang Chunfang, Chen Jiangtao, Liang Xueyan, Zhu Daiqian, Wang Junli, Lin Zongyun, Wei Yuxia, Li Jian, Lin Min

Abstract excerpt

BACKGROUND: Malaria remains a serious public health problem worldwide, particularly in Africa. Resistance to antimalarial drugs is an essential issue for malaria control and elimination. Currently, polymerase chain reaction (PCR) combined with Sanger sequencing is regarded as the gold standard for mutation detection. However, this method fails to meet the requirements of point-of-care testing (POCT) because of...

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Antimalarials
Argonaute Proteins
Biosensing Techniques
Chloroquine
Malaria, Falciparum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmodium falciparum

Protozoan Proteins

Pyrococcus furiosus

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Identifiers

PMID: 39582041
DOI: 10.1186/s13071-024-06575-0
PMCID: PMC11587582

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