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Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan.

Nature communications - 29 Oct 2024

Chen Hung-Lin, Chiang Hsiu-Yin, Chang David Ray, Cheng Chi-Fung, Wang Charles C N, Lu Tzu-Pin, Lee Chien-Yueh, Chattopadhyay Amrita, Lin Yu-Ting, Lin Che-Chen, Yu Pei-Tzu, Huang Chien-Fong, Lin Chieh-Hua, Yeh Hung-Chieh, Ting I-Wen, Tsai Huai-Kuang, Chuang Eric Y, Tin Adrienne, Tsai Fuu-Jen, Kuo Chin-Chi

Abstract excerpt

Current genome-wide association studies (GWAS) for kidney function lack ancestral diversity, limiting the applicability to broader populations. The East-Asian population is especially under-represented, despite having the highest global burden of end-stage kidney disease. We conducted a meta-analysis of multiple GWASs (n = 244,952) on estimated glomerular filtration rate and a replication dataset (n = 27,058)...

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ATP Binding Cassette Transporter, Subfamily G, Member 2
East Asian People
Glomerular Filtration Rate
Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multifactorial Inheritance

Neoplasm Proteins

Renal Insufficiency, Chronic

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Identifiers

PMID: 39472450
DOI: 10.1038/s41467-024-53516-7
PMCID: PMC11522641

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