Article
Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations.
Blood - 10 Mar 2011
Passamonti Francesco, Elena Chiara, Schnittger Susanne, Skoda Radek C, Green Anthony R, Girodon François, Kiladjian Jean-Jacques, McMullin Mary Frances, Ruggeri Marco, Besses Carles, Vannucchi Alessandro M, Lippert Eric, Gisslinger Heinz, Rumi Elisa, Lehmann Thomas, Ortmann Christina A, Pietra Daniela, Pascutto Cristiana, Haferlach Torsten, Cazzola Mario
Abstract excerpt
Although approximately 95% of patients with polycythemia vera (PV) harbor the V617F mutation in JAK2 exon 14, several mutations in exon 12 have been described in the remaining patients. We conducted a European collaborative study to define the molecular and clinical features of patients harboring these mutations. Overall, 106 PVs were recruited and 17 different mutations identified. Irrespective of the mutation,...
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