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Article

Translation of Mutant Repetitive Genomic Sequences in Hirsutella sinensis and Changes in the Secondary Structures and Functional Specifications of the Encoded Proteins.

International journal of molecular sciences - 17 Oct 2024

Li Xiu-Zhang, Li Yu-Ling, Wang Ya-Nan, Zhu Jia-Shi

Abstract excerpt

Multiple repetitive sequences of authentic genes commonly exist in fungal genomes. AT-biased genotypes of Ophiocordyceps sinensis have been hypothesized as repetitive pseudogenes in the genome of Hirsutella sinensis (GC-biased Genotype #1 of O. sinensis) and are generated through repeat-induced point mutation (RIP), which is charactered by cytosine-to-thymine and guanine-to-adenine transitions, concurrent...

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PMID: 39456960
DOI: 10.3390/ijms252011178
PMCID: PMC11508423

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