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LINC02253 promote the malignant phenotype of Colon adenocarcinoma cells by up-regulating WWP1-mediated SMAD3 ubiquitination.

Molecular and cellular probes - 1 Dec 2023

Wu Jinfeng, Lu Xianhong, Yu Jinzhong, Li Pan, Yu Xiqiu

Abstract excerpt

OBJECTIVES: Colon adenocarcinoma (COAD) represents a type of common malignant tumor originating in the digestive tract. Long non-coding RNAs (lncRNAs) have been identified to engage in regulating the initiation and development of COAD. LncRNA LINC02253 has been reported abnormal expressed in COAD, but the underlying mechanism has not been discussed so far. This study aimed to determine the role and the molecular...

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Adenocarcinoma
Colonic Neoplasms
MicroRNAs
Phenotype
Smad3 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ubiquitin-Protein Ligases

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PMID: 37597669
DOI: 10.1016/j.mcp.2023.101928

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