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Article

The dopamine transporter inhibition using GBR 12909 as a novel pharmacological tool to assess bipolar disorder-like neurobehavioral phenotypes in zebrafish.

Behavioural brain research - 4 Feb 2025

Canzian Julia, Borba João V, Resmim Cássio M, Mohammed Khadija A, Pretzel Camilla W, Adedara Isaac A, Rosemberg Denis B

Abstract excerpt

Dopamine (DA) is a neurotransmitter that plays an important role in brain physiology. Changes in DA-mediated signaling have been implicated with the pathophysiology of various neuropsychiatric conditions. Bipolar disorder (BD) is a mental disorder, characterized by alterning between manic/hypomanic and depressive mood. In experimental research, the pharmacological inhibition of DA reuptake using GBR 12909 serves...

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PMID: 39442564
DOI: 10.1016/j.bbr.2024.115302

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