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Article

Hypometric genetics: Improved power in genetic discovery by incorporating quality control flags.

American journal of human genetics - 7 Nov 2024

Tanigawa Yosuke, Kellis Manolis

Abstract excerpt

Balancing the tradeoff between quantity and quality of phenotypic data is critical in omics studies. Measurements below the limit of quantification (BLQ) are often tagged in quality control fields, but these flags are currently underutilized in human genetics studies. Extreme phenotype sampling is advantageous for mapping rare variant effects. We hypothesize that genetic drivers, along with environmental and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39442521
DOI: 10.1016/j.ajhg.2024.09.008
PMCID: PMC11568753

Genes

APOA5
APOC3
PDE3B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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