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Article

SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice.

PLoS genetics - 1 Jan 2013

Li Xiangming, Sanneman Joel D, Harbidge Donald G, Zhou Fei, Ito Taku, Nelson Raoul, Picard Nicolas, Chambrey Régine, Eladari Dominique, Miesner Tracy, Griffith Andrew J, Marcus Daniel C, Wangemann Philine

Abstract excerpt

Mutations of SLC26A4 are a common cause of human hearing loss associated with enlargement of the vestibular aqueduct. SLC26A4 encodes pendrin, an anion exchanger expressed in a variety of epithelial cells in the cochlea, the vestibular labyrinth and the endolymphatic sac. Slc26a4 (Δ/Δ) mice are devoid of pendrin and develop a severe enlargement of the membranous labyrinth, fail to acquire hearing and balance, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23874234
DOI: 10.1371/journal.pgen.1003641
PMCID: PMC3708829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice.PMID 23874234Read ↗

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