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Article

The moderation effect of GSTM1/GSTT1 gene polymorphisms on the association of sperm mitochondrial DNA copy number and sperm mobility.

Scientific reports - 21 Oct 2024

Zhang Tingting, Zhang Shengnan, Zhang Chen, Liu Huan, Liu Mingming, Zhang Guang-Hui, Duan Guangcai, Chen Shuaiyin, Ren Jingchao

Abstract excerpt

Oxidative stress (OS) is believed to be a significant factor in the decline of semen quality, with mitochondrial DNA copy number (mtDNAcn) serving as a sensitive biomarker for both semen quality and mitochondrial dysfunction resulting from oxidative stress. While glutathione S-transferases (GSTs) are commonly known as 'antioxidant' enzymes, there is ongoing debate regarding the relationship between GST genotypes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39433861
DOI: 10.1038/s41598-024-74968-3
PMCID: PMC11493958

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