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Quantifying Drosophila melanogaster Eye Phenotypes: A Computational Approach Integrating ilastik and Flynotyper.

Journal of visualized experiments : JoVE - 4 Oct 2024

Mujteba Qasim, Chalmers Madeleine R, Kim JiHye, Baek Minwoo, Kim Nam Chul

Abstract excerpt

The Drosophila melanogaster compound eye is a well-structured and comprehensive array of around 800 ommatidia, exhibiting a symmetrical and hexagonal pattern. This regularity and ease of observation make the Drosophila eye system a powerful tool to model various human neurodegenerative diseases. However, ways of quantifying abnormal phenotypes, such as manual ranking of eye severity scores, have limitations,...

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PMID: 39431770
DOI: 10.3791/67219

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