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Article

Zebrafish: An In Vivo Screening Model to Study Ocular Phenotypes.

Translational vision science & technology - 2 Mar 2022

Quint Wim H, Tadema Kirke C D, Crins Johan H C, Kokke Nina C C J, Meester-Smoor Magda A, Willemsen Rob, Klaver Caroline C W, Iglesias Adriana I

Abstract excerpt

Purpose: To establish a set of assays that allow the in vivo screening of candidate genes for ocular diseases in zebrafish, with an emphasis on refractive error. Methods: Our pipeline includes the most relevant ocular screening measurements to assess (1) ocular biometry using spectral domain optical coherence tomography, (2) refractive status using an eccentric photorefractor, (3) intraocular pressure by...

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Identifiers

PMID: 35285860
DOI: 10.1167/tvst.11.3.17
PMCID: PMC8934544

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