Article
Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster.
G3 (Bethesda, Md.) - 3 May 2016
Iyer Janani, Wang Qingyu, Le Thanh, Pizzo Lucilla, Grönke Sebastian, Ambegaokar Surendra S, Imai Yuzuru, Srivastava Ashutosh, Troisí Beatriz Llamusí, Mardon Graeme, Artero Ruben, Jackson George R, Isaacs Adrian M, Partridge Linda, Lu Bingwei, Kumar Justin P, Girirajan Santhosh
Abstract excerpt
About two-thirds of the vital genes in the Drosophila genome are involved in eye development, making the fly eye an excellent genetic system to study cellular function and development, neurodevelopment/degeneration, and complex diseases such as cancer and diabetes. We developed a novel computational method, implemented as Flynotyper software (http://flynotyper.sourceforge.net), to quantitatively assess the...
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