Article
JAK2V617F-dependent down regulation of SHP-1 expression participates in the selection of myeloproliferative neoplasm cells in the presence of TGF-β.
Journal of cellular and molecular medicine - 1 Oct 2024
Aoun Céline, Maslah Nabih, Ganesan Saravanan, Salomao Norman, Gendron Romane, Awan Toor Sarah, Letort Gil, Gou Panhong, Bonnamy Mélina, Parietti Véronique, Kiladjian Jean-Jacques, Giraudier Stephane, Cassinat Bruno
Abstract excerpt
Myeloproliferative neoplasms (MPNs) are characterized by an increased production of blood cells due to the acquisition of mutations such as JAK2V617F. TGF-β, whose secretion is increased in MPN patients, is known to negatively regulate haematopoietic stem cell (HSC) proliferation. Using an isogenic JAK2V617F or JAK2 wild-type UT-7 cell line we observed that JAK2V617F cells resist to TGF-β antiproliferative...
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