Article
N-Linked Fucosylated Glycans Are Biomarkers for Prostate Cancer with a Neuroendocrine and Metastatic Phenotype.
Molecular cancer research : MCR - 2 Jan 2025
Ippolito Joseph E, Hartig Jordan P, Bejar Kaitlyn, Nakhoul Hani, Sehn Jennifer K, Weimholt Cody, Grimsley Grace, Nunez Elena, Trikalinos Nikolaos A, Chatterjee Deyali, Kim Eric H, Mehta Anand S, Angel Peggi M, Troyer Dean A, Leach Robin J, Corey Eva, Wu Jennifer D, Drake Richard R
Abstract excerpt
Prostate cancer is a heterogeneous disease with a spectrum of pathology and outcomes ranging from indolent to lethal. Although there have been recent advancements in prognostic tissue biomarkers, limitations still exist. We leveraged matrix-assisted laser desorption/ionization imaging of formalin-fixed, paraffin embedded prostate cancer specimens to determine if N-linked glycans expressed in the extracellular...
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