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A prenatal skin atlas reveals immune regulation of human skin morphogenesis

16 Oct 2024

Abstract excerpt

. The SkO model closely recapitulated in vivo skin epidermal and dermal cell types during hair follicle development and expression of genes implicated in the pathogenesis of genetic hair and skin disorders. However, the SkO model lacked immune cells and had markedly reduced endothelial cell heterogeneity and quantity. Our in vivo prenatal skin cell atlas indicated that macrophages and macrophage-derived growth...

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PMID: 39415002
DOI: 10.1038/s41586-024-08002-x

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