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Large-Scale Comparative Analysis of Canine and Human Osteosarcomas Uncovers Conserved Clinically Relevant Tumor Microenvironment Subtypes

16 Oct 2024

Abstract excerpt

PURPOSE: Osteosarcoma is an aggressive bone cancer lacking robust biomarkers for personalized treatment. Despite its scarcity in humans, it is relatively common in adult pet dogs. This study aimed to analyze clinically annotated bulk tumor transcriptomic datasets of canine and patients with human osteosarcoma to identify potentially conserved patterns of disease progression. EXPERIMENTAL DESIGN: Bulk...

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PMID: 39412757
DOI: 10.1158/1078-0432.ccr-24-1854

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