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Association between human telomerase reverse transcriptase (hTERT) MNS16A polymorphism and risk of breast cancer.

Molecular biology reports - 16 Oct 2024

Salehi-Reyhani Seyede Mehrana, Saadat Mostafa

Abstract excerpt

BACKGROUND: It is well known that telomerase activity is suppressed in normal human tissues and reactivated in tumors, suggesting that the human telomerase reverse transcriptase (hTERT, MIM: 187270) gene may be involved in carcinogenesis. A polymorphic tandem repeat minisatellite located downstream of exon 16 of hTERT and upstream in the putative promoter region of an antisense hTERT transcript, termed MNS16A,...

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PMID: 39412736
DOI: 10.1007/s11033-024-09999-0

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