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In search of the genetic variants of human sex ratio at birth: was Fisher wrong about sex ratio evolution?

Proceedings. Biological sciences - 1 Oct 2024

Song Siliang, Zhang Jianzhi

Abstract excerpt

The human sex ratio (fraction of males) at birth is close to 0.5 at the population level, an observation commonly explained by Fisher's principle. However, past human studies yielded conflicting results regarding the existence of sex ratio-influencing mutations-a prerequisite to Fisher's principle, raising the question of whether the nearly even population sex ratio is instead dictated by the random X/Y...

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PMID: 39406345
DOI: 10.1098/rspb.2024.1876
PMCID: PMC11479764

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