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Article

Outer membrane barrier impairment by envC deletion reduces gut colonization of Crohn's disease pathobiont Escherichia coli.

Microbiology (Reading, England) - 1 Oct 2024

Miki Tsuyoshi, Ito Masahiro, Haneda Takeshi, Kim Yun-Gi

Abstract excerpt

Adherent-invasive Escherichia coli (AIEC) has been implicated in the aetiology of Crohn's disease (CD), a chronic inflammatory disorder of the gastrointestinal tract. The presence of Enterobacteriaceae, including AIEC, is heightened in the intestines of CD patients. Therefore, inhibiting AIEC colonization in the gastrointestinal tract could be a promising therapeutic intervention for CD. This study aims to assess...

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Identifiers

PMID: 39405098
DOI: 10.1099/mic.0.001509
PMCID: PMC11570989

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