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Article

Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly

1 Aug 2023

Abstract excerpt

Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information regarding the impact of age on responses to booster third doses. Here, we show that individuals 70 years or older (median age 73, range 70-75) who received a primary two-dose schedule with AZD1222 and booster third dose with mRNA vaccine achieve significantly lower neutralizing antibody...

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PMID: 37590132
DOI: 10.1016/j.celrep.2023.112991

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