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Effect of mutations in GDNV motif of viral hemorrhagic septicemia virus (VHSV) L protein on polymerase activity, viral growth, and in vivo virulence.

Virology - 1 Dec 2024

Kwak Jun Soung, Kim Jae Young, Kim Ki Hong

Abstract excerpt

Most Mononegavirales viruses have a GDNQ motif within the L protein, whereas Novirhabdovirus species feature a GDNV motif. This study examined the function of the GDNV motif within the L protein of viral hemorrhagic septicemia virus (VHSV) by modifying its amino acid composition. Substituting the aspartic acid (D) with valine (V) completely abolished polymerase activity in a minigenome assay. Replacing GDNV with...

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Amino Acid Motifs
Fish Diseases
Flounder
Novirhabdovirus
Rhabdoviridae Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Dependent RNA Polymerase

Virus Replication

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PMID: 39369673
DOI: 10.1016/j.virol.2024.110257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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