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A single amino acid change in the non-structural NV protein impacts the virulence phenotype of Viral hemorrhagic septicemia virus in trout.

The Journal of general virology - 1 Jun 2017

Baillon Laury, Mérour Emilie, Cabon Joëlle, Louboutin Lénaïg, Quenault Hélène, Touzain Fabrice, Morin Thierry, Blanchard Yannick, Biacchesi Stéphane, Brémont Michel

Abstract excerpt

Novirhabdoviruses like the Viral hemorrhagic septicemia virus (VHSV) are rhabdoviruses infecting fish. In the current study, RNA genomes of different VHSV field isolates classified as high, medium or low virulent phenotypes have been sequenced by next-generation sequencing and compared. Various amino acid changes, depending on the VHSV phenotype, have been identified in all the VHSV proteins. As a starting point,...

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PMID: 28640747
DOI: 10.1099/jgv.0.000830

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