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Spatial heterogeneity of infiltrating immune cells in the tumor microenvironment of non-small cell lung cancer

3 Oct 2024

Abstract excerpt

• Immune cells showed heterogeneous distribution in TME of NSCLC. • Efficientnet-B3-based model realized tumor and immune region segmentation. • TIME could be classified into three groups according to CD8+ T-cell density. • Single chromogenic IHC slices overlapping could realize mIHC simulation. Tumor-infiltrating lymphocytes (TILs) are essential components of the tumor microenvironment (TME) of non-small cell...

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PMID: 39366301
DOI: 10.1016/j.tranon.2024.102143

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