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Article

Single Nucleotide Polymorphisms and Their Association with Coronary Artery Aneurysms and IVIG Resistance in Kawasaki Disease in Ireland.

Pediatric cardiology - 1 Jun 2026

Duignan S M, Brennan K, Connolly E, Watson A, Noone D, Dunne E, Gavin P, Flinn A, Ó Maoldomhnaigh C, Doyle S L, McMahon C J

Abstract excerpt

Kawasaki disease (KD) is the leading cause of acquired heart disease in children in developed countries. The exact aetiology remains a mystery but genetics play an important role. Treatment with intravenous immunoglobulin (IVIG) successfully reduces the prevalence of coronary artery aneurysm (CAA) formation, however, IVIG resistance affects 10-20% of patients. We aimed to assess whether single nucleotide...

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Identifiers

PMID: 40775473
DOI: 10.1007/s00246-025-03989-0
PMCID: PMC13144236

Genes

VEGFA
CD40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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