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Article

Association of PPARGC1A gene polymorphism and mtDNA methylation with coal-burning fluorosis: a case-control study.

BMC genomics - 30 Sept 2024

Song Juhui, Zhao Ansu, Li Ruichao, Luo Yunyan, Dong Yangting, Wang Chanjuan, Zhang Ting, Deng Jie, Qi Xiaolan, Guan Zhizhong, He Yan

Abstract excerpt

BACKGROUND: Coal-burning fluorosis is a chronic poisoning resulting from the prolonged use of locally available high-fluoride coal for heating and cooking. Prolonged fluoride exposure has been demonstrated to decrease PPARGC1A levels. Therefore, this case-control aims to evaluate the genetic association of PPARGC1A gene polymorphisms and methylation of the mitochondrial D-loop region with coal-burning fluorosis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

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Identifiers

PMID: 39350036
DOI: 10.1186/s12864-024-10819-9
PMCID: PMC11441093

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