Article
Obsessive-compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs.
Translational psychiatry - 9 Feb 2016
den Braber A, Zilhão N R, Fedko I O, Hottenga J-J, Pool R, Smit D J A, Cath D C, Boomsma D I
Abstract excerpt
Variation in obsessive-compulsive symptoms (OCS) has a heritable basis, with genetic association studies starting to yield the first suggestive findings. We contribute to insights into the genetic basis of OCS by performing an extensive series of genetic analyses in a homogeneous, population-based sample from the Netherlands. First, phenotypic and genetic longitudinal correlations over a 6-year period were...
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